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Furthermore, protein arginine methyltransferase 5 (PRMT5) plays a crucial role in regulating ferroptosis, as it methylates and stabilizes Kelch-like ECH-associated protein 1 (KEAP1), a ubiquitinating enzyme that blocks the NRF2/HO-1 pathway, increasing TNBC resistance to both ferroptosis and immunotherapy (Wang et al., 2023f)

doi: 10.1016/j.jagp.2017.10.010, 193